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Acute kidney injury has been reported, typically in the context of severe gastrointestinal adverse reactions leading to volume depletion

Biochem and Biophys Res Comm 505(3):865871

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Additionally, metformin not only influences glucose metabolism in TC cells, but also suppresses mitochondrial respiration, which adds to its antitumor effect [267]

In this group, 9% used the medications specifically to treat a chronic condition such as heart disease or diabetes, the highest rate of medical use across all age groups