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Key points Vascular damage in chronic kidney disease (CKD) increases the risk of stroke and cognitive impairment, with faster CKD progression linked to cerebral damage, subcortical infarcts and bloodbrain barrier disruption

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The incidence of severe hypoglycemia in pediatric patients with type 1 diabetes receiving TOUJEO as part of a multiple daily injection regimen was 6% at 26 weeks and the incidence of hypoglycemia accompanied by a self-monitored or plasma glucose value less than 54 mg/dL regardless of symptoms was 80.3%

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However, their updated guidelines emphasize more nuanced strategiesespecially for patients with existing cardiovascular or kidney issues