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Safety analyses were also conducted on all who received at least one dose of the trial medication

J Exp Orthop 6(1):24 Krogh TP, Ellingsen T, Christensen R, Jensen P, Fredberg U (2016) Ultrasound-guided injection therapy of achilles tendinopathy with platelet-rich plasma or saline: a randomized, blinded

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Basically, cyanocobalamin needs to be broken down to cobalamin and cyanide in order to convert to the active form of B12, and some researchers have concerns about the effects of cyanide accumulation in the body with long-term use of cyanocobalamin but the jurys still out on whether thats a cause for concern