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2019) can be divided into two groups: Studies that suggest that NM concentrations per NM + CA neuron are quantitatively associated with cell death but are not higher in PD Mann and Yates (1983) found that in NM + neurons of the SN the NM optical density (an estimation of the relative NM amount which is not without technical issues) was, on average, lower per cell in eight PD patients compared to 20 age-matched controls, and that the frequency histograms of these results showed a direction as in our Fig