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The combination is studied because of their complementary mechanisms of action

doi:10.1016/j.ejphar.2013.10.033

The reduced demand for excess insulin secretion allowed for -cell rest and functional recovery 10

Inhibiting glycolysis through hexokinase knockdown in preclinical models acutely attenuated microglial activation and proinflammatory cytokine release after ischemic injury [65]