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Dose escalation speed and individual receptor sensitivity appear to influence the side effect burden more than which specific drug is chosen

Lees says

Moreover, some signalling assays are likely to represent the composite effect of more than one upstream process and inherent differences between how these responses are generated in different cell types could confound translation of signalling profiles from heterologous systems to native tissues

Additionally, glutathione has been used in the management of conditions such as Parkinson's disease, cystic fibrosis, and for its potential skin-lightening effects by inhibiting melanin synthesis