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This system features a dual-layer design: the outer layer incorporates acid-sensitive, photoactivatable ARV771 PROTAC nanoparticles (PPT7 NPs) that remain inert until triggered by the acidic tumor milieu, enabling precise, light-induced BRD4 degradation

Laffel LM, Kanapka LG, Beck RW, et al

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We next hypothesised that NADP oxidation during hypoxia may be due to NADPH consumption by the antioxidant machinery which is not matched by the rate of resupply due to limitations in flux through central metabolism

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