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When NAD+ levels drop, ATP production becomes less efficient

Autoimmune thyroid disease (AITD) was probably first described in 1912 when a Japanese physician, Hakaru Hashimoto, reported a condition where the thyroid was infiltrated by lymphocytes resulting in the production of anti-thyroid antibodies ( Reference Hashimoto 3 )

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10.1016/j.cell.2012.03.042 Cell 9 Friedmann AngeliJ