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Description

Cooperberg PL, Burhenne HJ

The peptide has a short half-life of approximately 15 minutes in vitro due to degradation by aminopeptidase-like enzymes, though research suggests it may be more stable in vivo due to binding interactions with carrier molecules in circulation

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To produce prolonged release in vivo, one particular analog with increased and balanced GCGR/GLP-1R activations was chemically linked with polyethylene glycol (PEG)