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The skin discoloration can be treated with pigment-specific lasers (eg, the Q-switched ruby, alexandrite, or Nd-YAG)

This promotes the growth of Escherichia coli and enhances choline degradation by upregulating the cutC gene, which is implicated in the transformation of choline to TMA, hence increasing TMAO levels (161)

Sobo or their prescribing clinician when side effects are persistent, worsening, confusing, or interfering with nutrition, hydration, bowel function, energy, sleep, or daily life

Further investigations can include a validation study of the genes involved in the skin irritation mechanism following direct treatment to cells

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury

Lerma-Cabrera, I