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This reflected different cut-off values of fasting GLP-1 levels employed in defining low and high GLP-1 groups

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Never cut or alter a patch in any way

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK as Mounjaro for the treatment of type 2 diabetes mellitus and as Zepbound for weight management in adults with obesity or overweight with weight-related comorbidities (BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity)

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