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2 Currently, disease-modifying osteoarthritis drugs (DMOADs) are lacking, leaving patients with limited options, ranging from pain management in the early stages to surgical joint replacement in advanced ones

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Multiple genetic variants and environmental factors are involved in RA

Ginsenoside Rg1, ginsenoside Re, notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rd are the main saponins that cause these effects [286]

Senescent VSMCs exhibit upregulation of RUNX2, while knockdown of RUNX2 resulted in a significant reduction of osteoblast markers, as well as in calcification (77)

Causes of Peripheral Neuropathy