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Apart from the cool cooling sensation (that might last up to 70 mins!), it also has painkilling, itch reducing, antibacterial, antifungal and even penetration enhancing properties

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A no-effect dose for adverse effects on pre- and postnatal development in rats was not established

However, unlike Sam68, such arginine methylation weakens its RNA-binding capability and inhibits its activity as an IRES trans-acting factor [182-184]