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It was previously reported that donor cells, HEK293, and COS-7 cells were transfected with miRNA, which targeted EGFR, and secreted sEVs overexpressing the miRNA (126)

10.3389/fimmu.2024.1467052 68 WeaverK.SkoutaR

Al-Qadhi HI

The normal levels may vary slightly between different labs but generally below 140pmol/L is considered a deficiency

Because of this, higher doses, typically 5001,000 mg per day, are often required to see measurable benefits (NIH)