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The high initial cost and technical complexity of the required equipment are significant barriers to large-scale industrial application ( 3.1.5 Subcritical water extraction method Also known as hot liquid or superheated water extraction ( Subcritical water extraction offers green, efficient technology for polyphenol extraction, but has several limitations

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Self-reported community sources commonly describe starting at very low doses (10-25% of the typical maintenance dose) and slowly titrating upward to reduce this

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Monitoring and follow-up are essential during the initial treatment period