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Circulation 116 (12), 14131423

As a multifunctional transmembrane glycoprotein, CD44 primarily interacts with hyaluronic acid, a major extracellular matrix (ECM) component, as well as growth factors and cytokines in the TME

More than 1,000 participants took part in this trial, and the results were striking: 10,800 FU/day of nattokinase (not the traditionally recommended 2,000 FU) produced meaningful improvements across cardiovascular markers, including lipids, carotid intima-media thickness, and plaque size

2010 Nov 15

500 mg daily) and gradually uptitrating to 2 grams daily, avoiding consumption on an empty stomach and using slow-release or extended-release formulations