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It also regulates appetite and caloric intake, and the GLP-1 receptor is present in several areas of the brain involved in appetite regulation

Whilst the synthesis of Romariz and colleagues supports the proposal that GLP-1 agonists are effective for weight loss in patients younger than 12, this is based only on 2 randomised controlled trials, both of which used liraglutide

Abo-Elmaaty AMA, Behairy A, El-Naseery NI, Abdel-Daim MM

One-fifth were familiar with the brand name Wegovy

The mechanism operates through two parallel pathways

As care decentralizes, evidence generation has to follow the patient, not just the claim