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Bjorklund reported that she had spent time in the emergency room and had her teeth fall out due to excessive vomiting

While in broad terms we now know that excessive collagen deposition drives fibrosis and excessive immune component mediates arthritis, the exact pathogenic mechanisms of fibroblasts in other contexts like fibromyalgia or frozen shoulder are not so well understood and are fundamental to know how to target these cells therapeutically and how to shift them back to homeostatic states

Contribution statement Both authors wrote and edited the manuscript and approved the final version

To help people with these risks, doctors encourage people to change their lifestyles, eat a heart-healthy diet and exercise consistently

Enzymes were extracted using 100 mM phosphate buffer (pH 6.8) containing KH 2 PO 4 and K 2 HPO 4

NAC was obtained from Sigma-Aldrich