Thyroid disorders, including Hashimotos thyroiditis and hypothyroidism, are common in people with metabolic diseases like diabetes and obesity
Retatrutide's 24.2% came at 48 weeks
However, isolated, mild hives are manageable with antihistamines and do not necessarily require stopping retatrutide
Repetition Range: 6-15 reps per set Lower body: 8-12 reps (legs can handle slightly higher reps) Upper body: 6-10 reps (upper body responds well to moderate-lower reps) Isolation work: 12-15 reps (accessory movements benefit from higher reps) Sets Per Exercise: 2-4 sets Beginners: 2 sets per exercise, focus on form Intermediate: 3 sets per exercise Advanced: 3-4 sets for compound movements, 2-3 for isolation Weekly Volume Per Muscle Group: 10-20 sets Large muscles (legs, back, chest): 12-20 sets weekly Smaller muscles (arms, shoulders): 10-15 sets weekly During aggressive caloric restriction, stay toward lower end of ranges Load Selection: 60-80% of 1-rep max Choose weights where the last 2 reps of each set are challenging but achievable with good form If you can complete 12+ reps easily, increase weight If you cant reach 6 reps with good form, decrease weight Rest Periods: 2-3 minutes for compound movements, 60-90 seconds for isolation exercises Sample Training Programs Program 1: Full Body (3x Weekly) Workout A, B, C (rotate through the week) Workout A: Barbell Back Squat: 3 sets x 8-10 reps Barbell Bench Press: 3 sets x 6-8 reps Barbell Row: 3 sets x 8-10 reps Dumbbell Shoulder Press: 2 sets x 10-12 reps Romanian Deadlift: 3 sets x 10-12 reps Plank: 3 sets x 45-60 seconds Workout B: Deadlift: 3 sets x 6-8 reps Incline Dumbbell Press: 3 sets x 8-10 reps Lat Pulldown: 3 sets x 10-12 reps Bulgarian Split Squat: 3 sets x 10-12 reps per leg Face Pulls: 2 sets x 15-20 reps Hanging Leg Raises: 3 sets x 10-15 reps Workout C: Leg Press: 3 sets x 10-12 reps Overhead Press: 3 sets x 6-8 reps Dumbbell Row: 3 sets x 8-10 reps per arm Walking Lunges: 3 sets x 12-15 reps per leg Dumbbell Chest Fly: 2 sets x 12-15 reps Bicycle Crunches: 3 sets x 20 reps Program 2: Upper/Lower Split (4x Weekly) Monday/Thursday: Upper Body Barbell Bench Press: 3 sets x 6-8 reps Pull-Ups or Lat Pulldown: 3 sets x 8-10 reps Overhead Press: 3 sets x 8-10 reps Cable Row: 3 sets x 10-12 reps Dumbbell Lateral Raises: 2 sets x 12-15 reps Bicep Curls: 2 sets x 10-12 reps Tricep Pushdowns: 2 sets x 12-15 reps Tuesday/Friday: Lower Body Barbell Back Squat: 4 sets x 8-10 reps Romanian Deadlift: 3 sets x 10-12 reps Leg Press: 3 sets x 12-15 reps Leg Curl: 3 sets x 10-12 reps Bulgarian Split Squat: 2 sets x 10-12 reps per leg Calf Raises: 3 sets x 15-20 reps Plank: 3 sets x 60 seconds Training Intensity and Progression During Retatrutide treatment, managing training intensity requires different thinking than traditional strength programs
In study settings, these pathways have been associated with shifts in energy balance, reduced food intake, fat-store reduction, and changes in metabolic biomarkers relative to single-pathway agents
However, compounded versions are not FDA-approved, and quality, safety, and effectiveness may differ from branded products
