In primary human skeletal muscle myoblast cultures (serum-free, 72 h), IGF-1 LR3 (10 nM) produces 4856 h sustained pAkt(Ser473) elevation (+2.22.8 over baseline), whereas equimolar native IGF-1 shows peak pAkt at 612 h and return to baseline by 2430 h due to IGFBP-3 sequestration
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The most effective laxatives are osmotic laxatives, such as polyethylene glycol (Gavilax, Miralax)
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