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Visceral adiposity is more strongly linked to endothelial dysfunction than subcutaneous fat, making the triple-agonist mechanism particularly relevant to vascular erectile physiology

Design: Randomized, double-blind, placebo-controlled Phase 2 trial

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In contrast, the SOUL trial, which enrolled a higher-risk population, showed a significant reduction in MACE with oral semaglutide [21]

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Most GI side effects resolve within 7 to 14 days at the new dose level