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Full structural recovery and return to unrestricted activity typically occurs between months 4 and 6 for significant tendon injuries

Risk factors include genetic predisposition, prenatal and birth complications, infections and immune dysfunction, and cannabis use as well as psychosocial factors such as childhood trauma or migration

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To explore the idea that matured aged MCs migrate from the periphery, to the injured brain and exacerbate HA mediated neuroinflammation, we used aged mast cell deficient c-Kit wsh /cKit wsh mice (12 months)