It's Usually Not The High Levels It's How You Process The B12 What's actually driving the side effects most of the time is something intrinsic to how that particular person is processing the vitamin B12
doi: 10.1038/srep32206 (2016)
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What the published data shows: According to a 2024 comparative review (Wei and Xu, 2024), which synthesizes findings from the SURMOUNT phase 3 tirzepatide trials (Jastreboff et al., NEJM 2022) and semaglutide data (Fras et al., NEJM 2021): Tirzepatide at the highest studied dose produced average excess weight loss that exceeded semaglutide comparators in reviewed cohorts Both drugs showed significant weight reduction versus placebo across trial populations Tirzepatide showed improvements in blood pressure, lipid profiles, and glycemic markers in obesity cohorts, beyond weight loss alone Important clinical caveat Trial results are population averages
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Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity
