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6 Preclinical data often report effects on neurotrophic and inflammatory pathways, but translation to clinically meaningful outcomes in humans depends on population, dose, and intervention duration

doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy

If a mouse failed to locate the platform within 1 min, the experimenter gently guided it onto the platform and allowed 10s of spatial orientation

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