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GLP-1-based compounds work primarily through appetite suppression, and the weight loss they produce includes significant lean mass loss (approximately 40% of total weight lost is lean tissue based on STEP trial data)

Free Radic Biol Med 223:263280 Xue Q et al (2023) Copper-dependent autophagic degradation of GPX4 drives ferroptosis

binding of Glc-6-P to the N -terminal domain inhibits the activity of the enzyme and production of Glc-6-P at the active site in the C-terminal domain

Progression of aortic valve stenosis: tgf-1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

Thus, we used an H 2 O 2 -damaged skin cell model treated with different concentrations of H 2 O 2 at various times