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The menopause transition is linked with real body changes: one meta-analysis found higher BMI, body fat, waist size, and visceral fat after menopause, and a newer review described the same shift toward more weight around the middle

To learn more about some of the other players, go to our Ups and Downs of Insulin Resistance series

For total ATP content measurements, cells were lysed with CellTiter-Glo Reagent (Promega Corporation, Madison, WI, USA) and total ATP determined

Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig

Piperidine: This corrosive chemical strips away protective groups from amino acids, allowing them to couple in the correct sequence and thereby develop into long peptide chains

If you have access to a DEXA/CT/MRI measurement of your visceral adipose tissue score, this helps define a metabolically healthy waist target