however, it is believed that the improvement is better with liraglutide over exenatide (32.1% vs 2.7%).[27,41] It suppresses glucagon (improved fasting hyperglycemia), delays gastric emptying via ileal-break mechanism, and improves hepatosteatosis.[41] GLP-1 Analogues and Renal System : It has shown to reduce albuminuria independent of the presence of other poor prognostic markers (poor diabetes control, hypertension, etc).[41] GLP-1 Analogues and Bone protection : Via its antagonistic action on neuropeptide Y, it has shown to improve bone mass.[41] GLP-1 Analogues and skin protection : Independent reports are emerging suggesting a potential beneficial role of liraglutide and exenatide in psoriasis via its influence on natural killer cells (implicated in pathogenesis of psoriasis).[45] GLUCAGON-LIKE PEPTIDE COMBINATION THERAPY GLP-1 analogues are currently approved for treatment of T2DM as monotherapy and as add-on therapy to existing anti-diabetes medication (mono, dual, or triple therapy)

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Cycle responsibly As with most peptide therapies, these therapies need to be in cycles and are not meant for continuous use