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Hyperglycemia influx to the glycolytic pathway and activation of the polyol pathway result in NADH overproduction and higher ROS levels (Mima, 2016)

This reduction correlates with many age-related diseases and chronic conditions

Ursoniu S, Sahebkar A, Serban M, Banach M (2015) Systematic review/meta-analysis lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials

Polyphenols mediate neuroprotection in cerebral ischemic stroke-an update

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References: Katzung BG (2021): Introduction to Autonomic Pharmacology (Chapter 6)