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The decades of research on CR suggest that the reduction in cancer incidence in CR is facilitated by the reduction in glucose, insulin, and IGF-1 levels, which would otherwise stimulate cell growth and proliferation, and the reduction in oxidative stress and inflammation (49, 50)

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Targeted placement of dermal fillers in these deflated superficial fat compartments alone or in combination with collagen biostimulators (for moderate-severe changes) can provide immediate volumisation and structural support, with the stimulation of collagen support from the collagen biostimulators