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PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system

403,404,405,406,407,408 These include KRAS -mutant pancreatic cancers, BRAF V600E -driven brain tumors, and STAT3-high breast cancers

Br J Pharmacol 179:677694