tirzepatide to retatrutide conversion How switch from to (full guide, dosing included) : r/USPeptides Retatrutide, Retatrutide vs. Tirzepatide, Retatrutide

doi: 10.1038/s41380-022-01792-4 68

By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion

[PubMed: 2981086] 89

Certain patient populations warrant thorough discussion of liver-related considerations before initiating GLP-1 receptor agonist therapy

I had not seen the data suggesting increased GERD-related complications, such as Barretts, as a result

Funding Open access funding provided by Universit degli Studi di Bari Aldo Moro within the CRUI-CARE Agreement