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5 Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, Peoples Republic of China

The skin of the hind limbs was incised, and the tibiae and femora were carefully dissected and stripped of surrounding soft tissues

Philadelphia, Pa: Saunders Elsevier

Accessed May 2026

(PMID 30895708) found oral 500 mg/day reduced melanin index in sun-exposed skin but effects were modest, temporary, and observed in Asian populations only