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Highly reactive species such as hydroxyl radical (OH) and perhydroxyl radical (HO 2 ) emerge from secondary interactions involving O 2 - NAFLD progression is further driven by insulin resistance (IR), ER stress, and the activation of the unfolded protein response (UPR) pathway [52, 53]

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The proven cardiovascular benefits of Semaglutide in the SELECT trial establish that GLP-1 agonism provides heart protection