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Due to inadequate insurance coverage, limited availability, and high costs, many people are turning to compounded GLP-1 RAs, which are often cheaper and easier to access but lack standardized efficacy, safety, and dosage information, and their safety profile is largely unknown

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[62] PHA-665752 (Pfizer) specifically inhibits MET kinase activity, and it has been demonstrated to represses both HGF-dependent and constitutive MET phosphorylation

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and recent FDA guidance has aimed to eliminate this production

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