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The three rodent strains were selected based on their established responsivity to alcohol and gut-brain peptides (22-24, 80)

The physiology is poorly understood, but may relate to changes in hypothalamic thermoregulation associated with fluctuations in estrogen levels

As PDs action, motor, somatic, arousal and cognitive symptoms are not effector specific, but are multidomain and affect the whole body, SCAN dysfunction might contribute to its pathophysiology, and therefore SCAN-specific neuromodulation might help to treat its symptoms 37,38

Rather, it facilitates weight loss primarily through appetite suppression and improved metabolic regulation, which can lead to a reduction in overall body fat, including abdominal fat, when combined with appropriate lifestyle modifications

Constipation is a risk factor for peritonitis due to intestinal bacterial translocations [2]

NICE recommends these for certain musculoskeletal conditions