The National Institute for Health and Care Excellence (NICE) recommends GLP-1 receptor agonists for type 2 diabetes as part of dual or triple therapy when metformin and other oral agents have not achieved adequate glycaemic control (NG28)
Key Takeaways GLP-1 drugs like Ozempic may cause dry mouth, gum inflammation, and dental complications
Whether this translates to humans is not established
The body's metabolic adaptations to weight lossincluding decreased energy expenditure, increased hunger hormones, and reduced satiety signalspersist long after weight reduction, making weight maintenance challenging without continued intervention
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Rachel Brazil looks at the difficulties in making the peptides themselves, and whats coming next Its rare that the public becomes aware of a recently approved drug, but the chances are youve heard of semaglutide, or its tradename Ozempic, one of a growing number of drugs that replicates the action of the natural hormone, glucagon-like peptide-1