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Its a by-product of normal cellular metabolism

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Collagen is the "glue" that holds the body together, preserving its shape and integrity

At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)