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The mechanistic logic NNMT inhibition preserving NAD+ salvage, increasing adipocyte energy expenditure, and protecting against diet-induced adipose accumulation in animal models places 5-Amino-1MQ in a distinct niche compared to the metabolic peptides that dominate the rest of the obesity-research landscape

selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]

That's better than nothing, but it's not the same as Phase 2 safety data

[DOI] [PubMed] [Google Scholar] 14.Lau SJ, Sarkar B

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