Models for nephrotoxicity screening Conventional in vitro models Until recently, researchers were left with only two options: in vitro cultures of primary human cells or the use of animal models, both having limitations
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Funding Open Access funding enabled and organized by CAUL and its Member Institutions Receipt of the Australian Government Research Training Program Domestic Fee Offset and the University of South Australia Postgraduate Research Award
Quick Answer: Glutathione is the body's primary antioxidant, but it is traditionally difficult to absorb orally
Both the oxidation of nutrients in the mitochondria and the oxidation of nascent proteins in the ER generate toxic reactive oxygen species (ROS): in the mitochondria by electron leakage during oxidative phosphorylation (Murphy, 2009), and in the ER by catalysis of disulfide bond formation by ER oxidoreductase (ERO1) (Higa & Chevet, 2012)
Complementary approaches: Gentle movement and pacing strategies
