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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

Potential conflict of interest to note: Several of the study authors worked for the company who produced the product used in the study

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Compounded tirzepatide formulations containing vitamin B12 typically appear pink to light red, contrasting with FDA-approved tirzepatide (Mounjaro, Zepbound), which is clear and colorless to slightly yellow