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182 The senescence and exhaustion of HSCs are the core reasons for the decline in hematopoietic system function, involving multiple mechanisms such as telomere attrition, oxidative stress, inflammatory disorders and epigenetic disorders, which ultimately lead to anemia, immunodeficiency, and an increased risk of hematological diseases

Any family history of thyroid cancer or medullary thyroid carcinoma raises additional scrutiny since semaglutide carries a black-box warning related to animal thyroid studies

Semaglutide is used on-label for people with a BMI over 30 or overweight with accompanied co-morbidities (i.e

so far I have not noticed any difference

Tirzepatide, a newer drug, is a dual GIP and GLP-1 receptor agonist, offering a broader approach by targeting multiple pathways to control blood sugar and promote weight loss, potentially providing more pronounced effects than semaglutide

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