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Its weight loss is meaningfully lower than injectable semaglutide: in PIONEER 1, the trial behind its diabetes approval, the highest dose produced only about 2.6 kg of weight loss over 26 weeks, versus roughly 15% body weight with injectable semaglutide in STEP 1[1][6]

Last updated 10/2025

Thus, understanding how pharmacy and medical benefit design affects GLP-1 coverage is critical