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The modification allows retatrutide to stick to a protein called albumin in the blood

Pharmacological GLP-1 RAs replicate these actions, aiding in managing Type 2 diabetes mellitus (T2DM) and promoting weight loss (23)

Generally, GLP-1 agonist medications are FDA approved for adults aged 18 years and older with certain body mass indexes (BMI) (typically a BMI of 30 or above, or a BMI of 27 or above if you have a weight-related health condition such as hypertension, high cholesterol, weight-related anxiety, liver disease, sleep apnea or PCOS)

Zepbound is FDA-approved for chronic weight management and for moderate-to-severe obstructive sleep apnea in adults with obesity

A head-to-head trial would be the cleanest way to compare two medicines under the same rules