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The cooperative action of PGC-1 with SF-1/LRH-1 may contribute to regulation of progesterone synthesis driven by fatty acid oxidation-mediated OXPHOS [234]
Additionally, seniors may struggle with proper denture care, leading to hygiene issues
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While no clinical trial has tested this combination, the anti-apoptotic and antioxidant effects of HIF-PHIs provide a strong mechanistic rationale for synergistic use with agents targeting erythrocyte apoptosis pathways (e.g., Bcl-xL upregulation or NIX inhibition)
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