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Furthermore, descending inhibitory pathways, which modulate the visceral pain signal by releasing neurotransmitters such as opioids, noradrenaline, dopamine and 5-HT [94], are down-regulated in IBS patients as indicated by an increased somatic sensitivity [95]

The least severe diagnosis is ASD Level 1

The analysis primary outcome was a composite of several severe GI adverse events, including bowel obstruction, gastroparesis, acute pancreatitis, biliary disease and severe constipation

In: The Temporal Lobe, Handbook of Clinical Neurology

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