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It also has been described that -glutamylcysteine, the intermediate of GSH biosynthesis, is able to act as a Gpx1 cofactor in mitochondrial H 2 O 2 detoxification, mimicking the physiological properties of GSH (Quintana-Cabrera et al., 2012)

To validate macrophage activation, mouse bone marrow-derived macrophages were extracted and incubated with cancer cells, that have been treated with the nanoparticles

Glutathione is a powerful, naturally occurring antioxidant composed of 3 amino acids: cysteine, glycine, and glutamic acid

Additionally, urinary excretion of glutathione and cysteine surged significantly by 300-fold and ten-fold, respectively within just 90 minutes [7]

Bioinformatics 25 , i161-168

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