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The modification with folic acid is able to increase tumor cell uptake of this nanomedicine, thereby enhancing targeting specificity and improving efficacy
Additional risk factors include having your gut operated on, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders
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Anim Sci J 92:e13540 Sayed AM, Hassanein EHM, Ali FEM, Omar ZMM, Rashwan EK, Mohammedsaleh ZM, Abd El-Ghafar OAM (2021) Regulation of Keap-1/Nrf2/AKT and iNOS/NF-B/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: mechanistic insights and computational pharmacological analysis
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