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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Treatment did not affect GSH but raised the plasma concentrations of serine, homocysteine, cysteine, and folate, which are 1-carbon cycle metabolites

Genetic and metabolic studies have further shown that metabolites such as succinate and fumarate, which are generated under normal physiological conditions, are associated with tumorigenesis in several cancer types

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Specifically, an initial reduction followed by a substantial increase in beta-endorphin levels was observed, a pattern that suggests DSIPs impact on the opioidergic system, potentially playing a role in stress alleviation or adaptation processes