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Peer review Peer review information Nature thanks Lucas Sullivan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

2009) (Figures 14 and 15)

503A Compounding vs Research-Grade Tesamorelin Tesamorelin is not available as a commercial injectable outside the FDA-approved indication for HIV-associated lipodystrophy

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In contrast, under stress conditions Keap1 activity is inhibited by phosphorylation and free Nrf2 moves to the nucleus, where it binds to ARE in the regulatory regions of cytoprotective proteins and promotes transcription of antioxidant genes such as SOD, glutathione peroxidase (GPx), and GSH, and of phase II detoxifying enzymes such as heme oxygenase-1 (HO-1), glutathione transferases (GST), nicotinamide adenine dinucleotide phosphate (NADPH), and NAD(P)H dehydrogenase [quinone] 1 (NQO1) (Serafini et al., 2019)