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The trial was randomized but not blinded

Table 21

This unusual stability allows for more flexible administration routes and potentially less frequent dosing when oral delivery is employed, as peak plasma concentrations are reached more slowly and clearance follows a more gradual curve compared to subcutaneous injection

The REDEFINE trials reported gastrointestinal adverse events in 79.6% of CagriSema patients compared to 39.9% in placebo groups

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conducted a study using cytokine-treated tissue-engineered cartilage as an in vitro model of OA to perform transcriptomic analysis